Iyini i-Nitric oxide?
I-nitric oxide igesi ekhiqizwa amangqamuzana ahilelekile ekuvuvukeni okuhlobene nesifuba somzimba noma i-eosinophilic asthma.
Iyini i-FeNO?
Ukuhlolwa kwe-Fractional exhaled Nitric Oxide (FeNO) kuyindlela yokulinganisa inani le-nitric oxide ngomoya okhishiwe.Lokhu kuhlola kungasiza ekuhlonzweni kwesifuba somoya ngokubonisa izinga lokuvuvukala emaphashini.
I-Clinical Utility ye-FeNO
I-FeNO inganikeza isithasiselo esingavamisile sokuxilongwa kokuqala kwesifuba somoya i-ATS kanye ne-NICE incoma njengengxenye yezinkombandlela zabo zamanje kanye nama-algorithms okuxilonga.
| Abantu abadala | Izingane | |
| I-ATS (2011) | Phezulu: >50 ppb Okumaphakathi: 25-50 ppb Phansi:<25 ppb | Phezulu: >35ppb Okumaphakathi: 20-35 ppb Phansi:<20 ppb |
| I-GINA (2021) | ≥ 20 ppb | |
| I-NICE (2017) | ≥ 40 ppb | > 35 pb |
| Ukuvumelana kwe-Scottish (2019) | >40 ppb ICS-naive iziguli > Iziguli ezingama-25 ppb ezithatha i-ICS |
Izifinyezo: I-ATS, i-American Thoracic Society;I-FeNO, i-fractional ex- haled nitric oxide;I-GINA, i-Global Initiative ye-Asthma;ICS, i-corticosteroid ehogelwe;I-NICE, Isikhungo Sikazwelonke Sezempilo Nokunakekelwa Okuphambili.
Imihlahlandlela ye-ATS ichaza amazinga e-FeNO aphezulu, amaphakathi, naphansi kubantu abadala ngokuthi >50 ppb, 25 to 50 ppb, kanye <25 ppb, ngokulandelana.Ngenkathi kusezingane, amazinga e-FeNO aphezulu, amaphakathi, naphansi achazwa ngokuthi >35 ppb, 20 to 35 ppb, kanye <20 ppb (Ithebula 1).I-ATS incoma ukusetshenziswa kwe-FeNO ukusekela ukuxilongwa kwe-asthma lapho ubufakazi obuhlosiwe budingeka khona, ikakhulukazi ekuxilongweni kokuvuvukala kwe-eosinophilic.I-ATS ichaza ukuthi amazinga aphezulu e-FeNO (> 50 ppb kubantu abadala kanye> 35 ppb ezinganeni), lapho ehunyushwa esimweni somtholampilo, abonisa ukuthi ukuvuvukala kwe-eosinophilic kukhona ukuphendula kwe-corticosteroid ezigulini ezinezimpawu, kuyilapho amazinga aphansi (<25 ppb kubantu abadala futhi <20 ppb ezinganeni) kwenza lokhu kungenzeki futhi amazinga amaphakathi kufanele ahunyushwe ngokuqapha.
Imihlahlandlela yamanje ye-NICE, esebenzisa amazinga aphansi okunqanyulwa kwe-FeNO kune-ATS (Ithebula 1), incoma ukusetshenziswa kwe-FeNO njengengxenye yomsebenzi wokuxilonga lapho ukuhlonzwa kwesifuba somoya kucatshangelwa khona kubantu abadala noma lapho kunokungaqiniseki kokuxilonga ezinganeni.Amazinga e-FeNO aphinde ahunyushwe esimweni somtholampilo kanye nokuhlolwa okwengeziwe, okufana nokuhlola i-bronchial provocation kungase kusize ukuxilonga ngokubonisa ukusabela ngokweqile komgwaqo womoya.Imihlahlandlela ye-GINA iyayivuma indima ye-FeNO ekuhlonzeni ukuvuvukala kwe-eosinophilic ku-asthma kodwa okwamanje ayiboni indima ye-FeNO kuma-algorithms okuxilonga isifuba somoya.I-Scottish Consensus ichaza ukunqanyulwa ngokuya kokuchayeka kwe-steroid ngamavelu amahle okuthi >40 ppb ezigulini ezine-steroid-naive kanye >25 ppb ezigulini eziku-ICS.
Isikhathi sokuthumela: Mar-31-2022